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Synthesis and Biological Activity of 4‐Hydroxy‐3‐(1,5‐diaryl‐3‐ oxo‐pent‐4‐enyl)chromen‐2‐ones
Author(s) -
Jadhav Mohan R.,
Shinde Devanand B.
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090111
Subject(s) - chemistry , yield (engineering) , antimicrobial , biological activity , aldehyde , catalysis , antifungal , mass spectrum , condensation , organic chemistry , proton nmr , combinatorial chemistry , in vitro , biochemistry , medicine , ion , materials science , physics , dermatology , metallurgy , thermodynamics
The substituted warfarin acid chalcones have been prepared by condensation of warfarin acid and aromatic/aliphatic aldehyde using aq. NaOH as catalyst. The method is simple, cost‐effective and gives good yield in a short reaction time. All the compounds synthesized have been characterized by IR, NMR and Mass spectra. A new series of 4‐hydroxy‐3‐(3‐oxo‐1,5‐diaryl‐3‐oxo‐pent‐4‐enyl)‐chromen‐2‐ones were synthesized and submitted to biological activity. Result of the biological screening showed the compounds 3b , 3h being the most effective among the various treatments in antimicrobial screening. Compounds 3c , 3d , 3k and 3l showed moderate activity against the microorganisms tested. Compounds 3e , 3h have shown good antifungal activity.