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A Modified and Green Procedure for the Synthesis of β ‐Amido Ketones Using a Br?nsted‐Acidic Ionic Liquid as Novel and Reusable Catalyst
Author(s) -
Davoodnia Abolghasem,
Heravi Majid M.,
RezaeiDaghigh Leila,
TavakoliHoseini Niloofar
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090091
Subject(s) - chemistry , ionic liquid , aldehyde , catalysis , hydrogen sulfate , acetonitrile , ketone , sulfonic acid , organic chemistry , aryl , green chemistry , alkyl
A green and improved method for the synthesis of β ‐amido ketones through one‐pot multi‐component reaction of an enolizable ketone, aryl aldehyde, acetonitrile or benzonitrile in the presence of trimethylsilyl chloride using 3‐methyl‐1‐(4‐sulfonic acid)butylimidazolium hydrogen sulfate [(CH 2 ) 4 SO 3 HMIM][HSO 4 ], a Br?nsted‐acidic ionic liquid, as an effective and recyclable catalyst is described. The present methodology offers several advantages such as simple procedure with an easy work‐up, relatively short reaction time, and good to excellent yields.