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Efficient Synthesis of New Tetracyclic Benzofuro[3,2‐ d ]‐imidazo[1,2‐ a ]pyrimidine‐2,5‐(1 H ,3 H )‐diones
Author(s) -
Hu Yanggen,
Liu Min,
Ding Mingwu
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090072
Subject(s) - chemistry , pyrimidine , sodium ethoxide , selectivity , catalysis , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , ethanol
The aza‐Wittig reaction of iminophosphorane ( 1 ) with aromaic isocyanates gave carbodiimides ( 2 ), which were allowed to react further with ( ‐amino ester in the presence of a catalytic amount of sodium ethoxide to give selectively new tetracyclic benzofuro[3,2‐ d ]imidazo[1,2‐ a ]pyrimidine‐2,5‐(1 H ,3 H )‐diones ( 5 ) in good yields. X‐ray structure analysis of 5i verified the proposed structure and the reaction selectivity.