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Synthesis and in vitro Antimicrobial Activity of New Ethyl 2‐(Ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐ a ]quinolin‐4‐yl)ethanoate Derivatives
Author(s) -
Kategaonkar Amol H.,
Sadaphal Sandip A.,
Shelke Kiran F.,
Kategaonkar Atul H.,
Shingate Bapurao B.,
Shingare Murlidhar S.
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090060
Subject(s) - chemistry , antimicrobial , aspergillus niger , quinoline , bacillus subtilis , candida albicans , proton nmr , carbon 13 nmr , escherichia coli , elemental analysis , antibacterial activity , in vitro , antifungal , combinatorial chemistry , organic chemistry , stereochemistry , nuclear chemistry , bacteria , microbiology and biotechnology , biochemistry , biology , gene , genetics
A series of new ethyl 2‐(ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐ a ]quinolin‐4‐yl)ethanoate derivatives have been synthesized for the first time of tetrazolo[1,5‐ a ]quinoline derivatives. Elemental analysis, IR, 1 H NMR, 13 C NMR, 31 P NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram‐positive Bacillus subtilis , Gram‐negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity.