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Interaction between (1,1′‐Binaphthalene)‐2,2′‐diol and Lecithin Liposome
Author(s) -
Chen Liuhua,
Gan Lihua,
An Shenjing,
Zhu Dazhang,
Xu Zijie,
Hao Zhixian,
Chen Longwu
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090053
Subject(s) - liposome , chemistry , lecithin , partition coefficient , fluorescence , membrane , aqueous solution , chromatography , organic chemistry , biochemistry , physics , quantum mechanics
The interaction between (1,1′‐binaphthalene)‐2,2′‐diol (BINOL) and lecithin liposome was studied by UV‐Vis, fluorescence and 1 H NMR spectroscopies. BINOL can obviously associate with lecithin liposome and the preferential binding site of BINOL with lecithin liposome is located in the headgroup region. The hydrogen bond and electrostatic interaction should exist in BINOL/liposome system, which restricts intra‐annular rotation of naphthol moieties. Therefore, the fluorescence intensity of BINOL increases when a small quantity of liposome is added into the system. The partition coefficient K D between the lecithin liposome and the aqueous phase is 310.9. With the increase of BINOL concentration, the micropolarity ( I 1 / I 3 ) and membrane fluidity of liposome decreased, while the viscosity of membrane increased.