A Thermodynamic Study on the Binding of Human Serum Albumin with Lanthanum Ion | Zendy

Rezaei Behbehani G. | Zendy; Divsalar A. | Zendy; Saboury A. A. | Zendy; Faridbod F. | Zendy; Ganjali M. R. | Zendy

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A Thermodynamic Study on the Binding of Human Serum Albumin with Lanthanum Ion

Author(s) -

Rezaei Behbehani G.,

Divsalar A.,

Saboury A. A.,

Faridbod F.,

Ganjali M. R.

Publication year - 2010

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201090047

Subject(s) - chemistry , isothermal titration calorimetry , solvation , human serum albumin , lanthanum , cooperativity , calorimetry , enthalpy , titration , thermodynamics , serum albumin , ion , inorganic chemistry , chromatography , organic chemistry , biochemistry , physics

Thermodynamics of the interaction between lanthanum(III) ion, La 3+ , and human serum albumin (HSA), was investigated at pH 7.0 and 300 K in Tris‐HCl buffer by isothermal titration calorimetry. A solvation model was used to reproduce the enthalpies of HSA interaction with La 3+ . The solvation parameters recovered from our new model were attributed to the structural change of HSA and its biological activity. The interaction of HSA with La 3+ showed a set of two binding sites with negative cooperativity.

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