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Synthesis of N 1‐Substituted 1,2,3,6‐Tetrahydropyrimidin‐ 2‐ones via an Unexpected Reaction of Thiazolo[3,2‐ a ]‐pyrimidine Derivatives and Nitrile Oxide
Author(s) -
Li Xiaofang,
Yi Pinggui,
Yu Xianyong
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090042
Subject(s) - chemistry , nitrile , pyrimidine , domino , ring (chemistry) , cycloaddition , oxide , 1,3 dipolar cycloaddition , medicinal chemistry , stereochemistry , organic chemistry , catalysis
A new class of N 1‐substituted 1,2,3,6‐tetrahydropyrimidin‐2‐ones was prepared in moderate yields by the reaction of nitrile oxide with thiazolo[3,2‐ a ]pyrimidine derivatives via a domino 1,3‐dipolar cycloaddition/ring‐opening/ substitution process. The structures of the products were characterized thoroughly by IR, elemental analysis, MS, NMR together with X‐ray crystallographic analysis.