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Microwave Assisted One‐pot Synthesis of 2‐Amino‐4 H ‐chromenes and Spiropyrano[2,3‐ d ]pyrimidine
Author(s) -
Mahmoud Alaa F.,
Abd ElLatif Fathy F.,
Ahmed Amira M.
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090041
Subject(s) - malononitrile , chemistry , barbituric acid , isatin , reagent , pyrimidine , thiobarbituric acid , organic chemistry , one pot synthesis , combinatorial chemistry , stereochemistry , catalysis , antioxidant , lipid peroxidation
A convenient and efficient method using microwave assisted one pot synthesis reactions for synthesis of 4 H ‐benzo[ f ]chromenes by the reaction of aromatic aldehydes with a mixture of malononitrile and naphthols was examined. The synthesis of spiropyrano[2,3‐ d ]pyrimidines by the reaction of isatin with malononitrile and barbituric acid and/or thiobarbituric acid was investigated. The versatility of the method was also examined through the reaction of aromatic aldehydes and malononitrile with various reagents.