Synthesis, Structure and Anticancer Activity Studies of 1‐[(5‐Bromo‐2‐thienyl)sulfonyl]‐5‐fluoro‐1,2,3,4‐tetrahydropyrimidine‐2,4‐dione | Zendy

Miao Qian | Zendy; Yan Xiaowei | Zendy; Zhao Kejian | Zendy

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Synthesis, Structure and Anticancer Activity Studies of 1‐[(5‐Bromo‐2‐thienyl)sulfonyl]‐5‐fluoro‐1,2,3,4‐tetrahydropyrimidine‐2,4‐dione

Author(s) -

Miao Qian,

Yan Xiaowei,

Zhao Kejian

Publication year - 2010

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.201090039

Subject(s) - chemistry , sulfonyl , hydrogen bond , molecule , proton nmr , thermal stability , crystal structure , elemental analysis , cancer cell lines , stereochemistry , infrared spectroscopy , medicinal chemistry , crystallography , cancer cell , organic chemistry , cancer , medicine , alkyl

An anticancer active compound 1‐[(5‐bromo‐2‐thienyl)sulfonyl]‐5‐fluoro‐1,2,3,4‐tetrahydropyrimidine‐2,4‐dione ( 1 ) was synthesized by the modified Schotten‐Baumann reaction of 5‐fluorouracil with 5‐bromo‐2‐thienyl‐sulfonyl chloride and characterized by elemental analysis, IR, 1 H and 13 C NMR spectra. The single crystal X‐ray diffraction analysis shows that the title molecule forms a two dimensional sheet structure by three kinds of hydrogen bond interactions. Its thermal stability was studied by TGA technique. Based on inhibition ratio against cancer cell growth, compound 1 has obvious anticarcinogenic activity against HL‐60 and BEL‐7402 cancer cells.

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