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Pd/C‐catalyzed Reductive Mono‐ N ‐alkylation of Nitrophenol Derivatives in One‐pot Way
Author(s) -
Jin Zhonghao,
Li Dao,
Wang Xingyi,
Xiao Qin
Publication year - 2010
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.201090029
Subject(s) - chemistry , alkylation , alkyl , amine gas treating , catalysis , organic chemistry , medicinal chemistry , combinatorial chemistry
A range of different nitrophenol derivatives were converted in one‐pot to the corresponding secondary alkyl aminophenols in good to excellent yields by using ketones as alkyl source and hydrogen over 10 wt% Pd/C as reducing agent. In all examples, except for one, the secondary amine was the sole alkylation product isolated. When aldehydes were used as alkyl source, the corresponding tertiary amine as a sole alkylation product was isolated.