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Fluorapatite: An Effective Solid Base Catalyst for Michael Addition of Indole/pyrrole to Nitroalkenes under Solventless Condition
Author(s) -
Zhang Litao,
Zhang Lili,
Zou Jianping
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990373
Subject(s) - fluorapatite , chemistry , indole test , pyrrole , michael reaction , base (topology) , catalysis , organic chemistry , combinatorial chemistry , mineralogy , mathematical analysis , mathematics , apatite
Abstract Solid base fluorapatite was found to catalyze the Michael addition of indole/pyrrole to nitroalkenes efficiently under solventless condition, affording the products in good to excellent yields. The Michael addition occurred at the 3‐position of indole exclusively with an exception of 3‐methylindole. The synthetic fluorapatite could be recovered and reused easily without obvious loss in activity.