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Enantioselective Alkynylzinc Addition to Carbonyl Compounds by Tf‐based Sulfamide‐amine Alcohol Catalysis
Author(s) -
Li Hongwang,
Li Xincheng,
Xue Feng,
Huang Yongbo,
Jin Wei,
Wan Boshun
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990338
Subject(s) - sulfamide , chemistry , enantioselective synthesis , amine gas treating , alcohol , catalysis , organic chemistry
The new Tf‐based sulfamide‐amine alcohol 3a was found to be very effective in catalyzing the enantioselective alkynylzinc addition to both aromatic aldehydes and unactivated aromatic ketones without using another metal species under mild condition, providing up to 92% ee and 90% ee for aldehydes and ketones, respectively.