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A Facile Synthesis of N ‐Aryl Substituted Piperidones
Author(s) -
Geng Qian,
Zhang Hui,
Cao Weiguo,
Chen Yali
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990335
Subject(s) - chemistry , amination , aryl , yield (engineering) , hydrolysis , combinatorial chemistry , ligand (biochemistry) , ullmann reaction , proline , organic chemistry , catalysis , amino acid , biochemistry , alkyl , materials science , receptor , metallurgy
A general and efficient procedure for the synthesis of N ‐aryl‐substituted 4‐piperidones was developed. The two step syntheses proceeded with an overall yield of 60%‐83% using L ‐proline as the ligand for the Cu(I)‐catalyzed Ullmann amination followed by subsequent hydrolysis of resulting ketals.