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K 2 CO 3 ‐Promoted Cascade Michael‐Alkylation Reactions: A Facile Preparation of Diethyl trans ‐2,3‐Disubstituted 1,1‐Cyclopropanedicarboxylates
Author(s) -
Yang Gaosheng,
Hua Yuanyuan,
Shen Yue
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990305
Subject(s) - chemistry , alkylation , cyclopropane , michael reaction , cascade , medicinal chemistry , organic chemistry , catalysis , ring (chemistry) , chromatography
A cascade Michael‐alkylation reaction of diethyl benzylidenemalonates with chloroacetophenones was realized by using K 2 CO 3 as the promoter. With this method, a series of diethyl trans ‐2,3‐disubstituted 1,1‐cyclopropane‐ dicarboxylates have been facilely synthesized in moderate yields under mild conditions. The relative configurations of two typical products were confirmed by X‐ray crystallographic analysis.