Spectrophotometric Determination of Cimetidine through Charge‐transfer Reaction with 1,5‐Dichloroanthraquinone as a π‐Electron Acceptor | Zendy

WEI Xiaoling | Zendy; DU Liangwei | Zendy; WANG Lisheng | Zendy; WEI Chunliu | Zendy; JIANG Zhiliang | Zendy

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Spectrophotometric Determination of Cimetidine through Charge‐transfer Reaction with 1,5‐Dichloroanthraquinone as a π‐Electron Acceptor

Author(s) -

WEI Xiaoling,

DU Liangwei,

WANG Lisheng,

WEI Chunliu,

JIANG Zhiliang

Publication year - 2009

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200990274

Subject(s) - chemistry , cimetidine , detection limit , acetone , acceptor , absorption (acoustics) , charge transfer complex , analytical chemistry (journal) , charge (physics) , chromatography , photochemistry , organic chemistry , medicine , physics , acoustics , condensed matter physics , quantum mechanics

Cimetidine reacting with 1,5‐dichloroanthraquinone in acetone solution can produce a charge‐transfer complex that shows a strong absorption peak at 343 nm. The absorption value at 343 nm increased with cimetidine concentration in the range of 0.01–0.5 µg/mL, with regression coefficient of 0.9995 and detection limit of 0.006 µg/mL. This simple and sensitive method has been successfully applied to determine cimetidine in tablets and capsules, with average recovery of (98.47±0.92)% and (97.07±1.16)%, respectively. Furthermore, the mole ratio of the complex between cimetidine and 1,5‐dichloroanthraquinone is 2:1, and the mechanism of charge‐transfer reaction is explored.

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