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Manganese Dioxide Mediated Stereoselective, One‐step Synthesis of Novel Steroidal (6 R )‐Spiro‐1',2′,4′‐triazoline‐3′‐thiones
Author(s) -
SIDDIQUI Nazish,
SALIM Anwar,
AKRAM M. K.
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990256
Subject(s) - chemistry , manganese , reagent , stereoselectivity , medicinal chemistry , combinatorial chemistry , organic chemistry , catalysis
Oxidative cyclization of 5 α ‐cholestan‐6‐one thiosemicarbazone ( 1 ), its 3 β ‐chloro ( 2 ) and 3 β ‐acetoxy ( 3 ) analogues with active manganese dioxide at room temperature afforded selectively the corresponding (6 R )‐spiro‐1',2′,4′‐triazoline‐3′‐thiones 4 – 6 . This synthesis has the advantages of mild reaction conditions, easy handling, easily available reagent and high yields. The products have been characterized by analytical and spectral data.