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A Convenient Method to Construct Chroman Skeleton: Asymmetric Synthesis of (−)‐4′‐Hydroxy‐7‐methoxyflavane
Author(s) -
XU Boyan,
XUE Jijun,
ZHANG Huabing,
LI Ying
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990236
Subject(s) - chemistry , enantioselective synthesis , skeleton (computer programming) , construct (python library) , stereochemistry , key (lock) , formal synthesis , combinatorial chemistry , organic chemistry , catalysis , programming language , computer science , ecology , biology
The first enantioselective synthesis of a naturally occurring 4′‐hydroxy‐7‐methoxyflavane was developed by an asymmetric reduction and a microwave‐assistant aromatic C–O bond formation to construct the benzopyran skeleton. Key features of this method include its brevity, its preserved stereochemical integrity and two different synthetic routes to choose.