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Synthesis and Cytotoxicity of Derivatives of Fluorouracil Conjugated with Three‐membered Ring
Author(s) -
WANG Le,
ZHANG Yunxiao,
TAO Jingchao
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990229
Subject(s) - chemistry , conjugate , fluorouracil , ring (chemistry) , cytotoxicity , conjugated system , stereochemistry , in vitro , combinatorial chemistry , organic chemistry , biochemistry , cancer , polymer , medicine , mathematical analysis , mathematics
A novel series of 3‐membered ring fluorouracil conjugates including cyclopropylmethyl fluorouracil and (2,3‐epoxypropyl) fluorouracil conjugates were synthesized via selective protection, and their structures were confirmed by IR, 1 H NMR and HRMS. Cytotoxicities in vitro of these conjugates were evaluated. Compounds 7 , 8 , 12 and 13 have shown cytotoxicities against Ec9706 cells in different degrees.