Synthesis and Cytotoxicity of Derivatives of Fluorouracil Conjugated with Three‐membered Ring | Zendy

WANG Le | Zendy; ZHANG Yunxiao | Zendy; TAO Jingchao | Zendy

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Synthesis and Cytotoxicity of Derivatives of Fluorouracil Conjugated with Three‐membered Ring

Author(s) -

WANG Le,

ZHANG Yunxiao,

TAO Jingchao

Publication year - 2009

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200990229

Subject(s) - chemistry , conjugate , fluorouracil , ring (chemistry) , cytotoxicity , conjugated system , stereochemistry , in vitro , combinatorial chemistry , organic chemistry , biochemistry , cancer , polymer , medicine , mathematical analysis , mathematics

A novel series of 3‐membered ring fluorouracil conjugates including cyclopropylmethyl fluorouracil and (2,3‐epoxypropyl) fluorouracil conjugates were synthesized via selective protection, and their structures were confirmed by IR, 1 H NMR and HRMS. Cytotoxicities in vitro of these conjugates were evaluated. Compounds 7 , 8 , 12 and 13 have shown cytotoxicities against Ec9706 cells in different degrees.

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