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Generation of Pd Nanoparticles in situ from PdCl 2 in TBAF: An Efficient and Reusable Catalytic System for the Suzuki‐Miyaura Reaction under Ligand‐ and Solvent‐free Conditions
Author(s) -
TAO Liming,
XIE Yexiang,
DENG Chenliang,
LI Jinheng
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990228
Subject(s) - chemistry , aryl , catalysis , ligand (biochemistry) , halide , coupling reaction , palladium , solvent , combinatorial chemistry , nanoparticle , organic chemistry , nanotechnology , receptor , biochemistry , materials science , alkyl
Pd nanoparticles were generated in situ from PdCl 2 in TBAF ( n ‐Bu 4 NF), which displayed high efficiency for the Suzuki‐Miyaura cross‐coupling reaction. In the presence of PdCl 2 and TBAF, a variety of aryl halides were coupled with arylboronic acids smoothly in moderate to good yields. Moreover, the PdCl 2 /TBAF system could be recovered and reused several times in the Suzuki‐Miyaura reaction, and aryl bromides could be consumed completely by arylboronic acids in about 15–60 min. It is noteworthy that these reactions were conducted under solvent‐free, ligand‐free and reusable conditions. Mechanism for the PdCl 2 /TBAF‐catalyzed reactions was also discussed.