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Synthesis, Characterization and Antimicrobial Activity of Potassium Hydro(benzoyl)(phthalyl)borate and Its Cobalt(II), Nickel(II), and Copper(II) Complexes
Author(s) -
SHARMA Guruaribam Shashikumar,
SHEIKH Rayees Ahmad,
SHREAZ Sheikh,
HASHMI Athar Adil,
KHAN Luqman Ahmad
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990217
Subject(s) - chemistry , cobalt , nickel , nuclear chemistry , potassium , copper , ligand (biochemistry) , metal , zinc , octahedral molecular geometry , salt (chemistry) , boron , antibacterial activity , candida glabrata , inorganic chemistry , candida albicans , medicinal chemistry , bacteria , organic chemistry , biochemistry , receptor , biology , genetics
A new organoborate ligand, hydro(benzoyl)(phthalyl)borate has been synthesized as its potassium salt (KL) and treatment of KL with one equivalent of MCl 2 ·6H 2 O gave complexes ML(H 2 O) x ·Cl [ x =2, M=Co(II), Ni(II); x =1, M=Cu(II)]. All compounds were characterized by elemental analysis, FTIR, 1 H NMR, ESI MS, UV‐Vis techniques, conductivity and magnetic data measurements. Spectroscopic results suggest a square planar geometry in the Cu(II) complex, while the Co(II) and Ni(II) complexes possess an octahedral geometry. Antibacterial activities ( in vitro ) of the ligand and its metal complexes were studied against two Gram positive ( B. subtillis and B. magterium ) and two Gram negative bacteria ( E. Coli and S. boydi ) at a single concentration (75 µg/mL) by using the Disc diffusion method. Antifungal activities ( in vitro ) were also checked for the compounds by using the same method against Candida albicans 10261 , Penicillium sp. and Asperjillius niger ., at a single concentration (50 µg/mL). The results showed that all the metal complexes, specially the nickel(II) complex, have higher antibacterial and antifungal activities than the corresponding potassium salt.