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Synthesis, Characterization and Biological Activity of an Intramolecular Stacking Zinc(II) Complex
Author(s) -
GAO Enjun,
LIU Lei,
ZHU Mingchang,
WU Qiong
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990214
Subject(s) - chemistry , zinc , agarose gel electrophoresis , stacking , pbr322 , crystallography , intramolecular force , elemental analysis , ligand (biochemistry) , dna , stereochemistry , plasmid , inorganic chemistry , organic chemistry , biochemistry , receptor
The synthesis, crystallographic analysis and spectroscopic study of a zinc(II) complex [Zn(bipy)(pmal)(H 2 O)]· 2H 2 O (bipy=2,2′‐bipyridine, pmal=phenylmalonic acid) were carried out. The complex has been investigated by the methods of X‐ray crystallography, elemental analysis and IR spectra. The binding ability of the Zn(II) complex to calf thymus (CT‐DNA) was characterized by measuring the effects on the UV spectroscopy and fluorescence spectra of DNA. The agarose gel electrophoresis experimental results suggest that the ligand planarity of complex has a significant effect on cleaving the pBR322 plasmid DNA.