Premium
An Efficient Microwave‐assisted Synthesis of Pyrido[2,3‐ d ]pyrimidine Derivatives
Author(s) -
TU Shujiang,
WU Shanshan,
HAN Zhengguo,
HAO Wenjuan
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990192
Subject(s) - chemistry , barbituric acid , pyrimidine , microwave irradiation , acetic acid , ethylene glycol , catalysis , solvent , organic chemistry , microwave , combinatorial chemistry , stereochemistry , physics , quantum mechanics
A series of new pyrido[2,3‐ d ]pyrimidine derivatives were synthesized by multi‐component reactions of equimolar amount of aromatic aldehydes with barbituric acids (barbituric acid or 1,3‐dimethylbarbituric acid) and 5‐amino‐2‐methylbenzo[ d ]thiazol in mixed solvent of glacial acetic acid and ethylene glycol without catalyst under microwave irradiation. This one‐pot method has the advantage of good yields (90% –93%), simple workup procedure and short reaction time (5 min).