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An Efficient Four‐Component, One‐Pot Synthesis of Poly‐Substituted Pyrimidines in Water
Author(s) -
WANG Zhongqing,
GE Zemei,
CHENG Tieming,
LI Runtao
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990139
Subject(s) - chemistry , malononitrile , halide , environmentally friendly , carbon disulfide , alkyl , salt (chemistry) , solvent , component (thermodynamics) , reaction conditions , organic chemistry , combinatorial chemistry , scope (computer science) , one pot synthesis , catalysis , ecology , physics , thermodynamics , computer science , biology , programming language
An efficient environmentally friendly synthesis of poly‐substituted pyrimidines has been developed via a four‐component, one‐pot reaction of malononitrile, carbon disulfide, alkyl halide and S ‐alkylisothiouronium salt in water at room temperature. Water as solvent, mild reaction conditions, short reaction time, simple experimental procedures, broad scope of substrates and good yields are the main advantages of this method.