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Synthesis and Bioactivity of Some New 2‐(Alkoxy carbonyl alkyl)‐6‐bromo‐3,4‐dihydro‐3‐( α ‐methyl benzyl)‐2‐oxo‐benzo[e] [2H‐1,3,2‐oxazaphosphinine] Derivatives
Author(s) -
SRINIVASULU K.,
SURESH KUMAR K.,
HARI BABU B.,
STEPHEN BABU M. F.,
NAGA RAJU C.,
SURESH REDDY C.
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990135
Subject(s) - chemistry , triethylamine , alkyl , tetrahydrofuran , alkoxy group , toluene , medicinal chemistry , organic chemistry , solvent
Synthesis of some new 2‐(alkoxy carbonyl alkyl)‐6‐bromo‐3,4‐dihydro‐3‐( α ‐methyl benzyl)‐2‐oxo‐3‐benzo‐ [e][2 H ‐1,3,2‐oxazaphosphinine] derivatives was accomplished through a two step process, which involves the condensation of 2‐[( α ‐methylbenzyl amino)methyl]‐4‐bromophenol ( 1 ) with phosphorus oxychloride in equimolar quantities in the presence of triethylamine in dry toluene in 50–55 °C producing the corresponding intermediate ( 2 ), and subsequent reaction with the amino acid alkyl ester in dry tetrahydrofuran in the presence of triethylamine at different temperatures. They exhibited significant antibacterial and fungal activity.