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Synthesis of β ‐Hydroxy Sulfides via Thiolysis of Epoxides Using S ‐Alkylisothiouronium Salts as Thiol Equivalents in Basic Aqueous Medium
Author(s) -
ZHU Jirang,
LI Ridong,
GE Zemei,
CHENG Tieming,
LI Runtao
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990132
Subject(s) - chemistry , thiolysis , thiol , regioselectivity , aqueous medium , aqueous solution , organic chemistry , salt (chemistry) , combinatorial chemistry , catalysis , polyphenol , proanthocyanidin , antioxidant
S ‐Alkylisothiouronium salt as a nontoxic, odorless and simply operational alternative of thiol was reacted with different kinds of epoxides in basic aqueous medium at room temperature affording the β ‐hydroxy sulfides with high regioselectivity in excellent yields.