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Synthesis and Antiviral Activities of Chiral Thiourea Derivatives
Author(s) -
YAN Zhikun,
CAI Xuejian,
YANG Xuan,
SONG Baoan,
CHEN Zhuo,
BHADURY S. Pinaki,
HU Deyu,
JIN Linhong,
XUE Wei,
LU Ping
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990097
Subject(s) - thiourea , chemistry , ionic liquid , in vivo , solvent , proton nmr , bioassay , combinatorial chemistry , ionic bonding , nuclear chemistry , organic chemistry , catalysis , ion , genetics , microbiology and biotechnology , biology
An environmentally benign method has been developed for the synthesis of novel chiral thiourea derivatives in high yields in ionic liquid [Bmim]PF 6 . The ionic solvent can be recovered and reused without any loss of its activity. The target compounds were characterized by elemental analysis, IR, 1 H NMR and 13 C NMR spectral data. According to the preliminary bioassay, some of the chiral thiourea analogues exhibited moderate in vivo antiviral activities against TMV at a concentration of 500 mg/L. Title chiral compound 3i was found to possess good in vivo protection, inactivation and curative activities of 57.0%, 96.4% and 55.0%, respectively against TMV with an inhibitory concentration at 500 mg/L. The title chiral compound 3i revealed better inactivation effect on TMV (EC 50 =50.8 µg/mL) than Ningnanmycin (EC 50 =60.2 µg/mL).