Premium
Synthesis and Biological Activities of Novel Thiophosphoryl Oximates Containing Thiazole and 1,2,3‐Triazole Rings
Author(s) -
ZHU Xiaofei,
SHI Deqing
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990092
Subject(s) - chemistry , thiazole , triazole , oxime , proton nmr , carbon 13 nmr , bioassay , stereochemistry , organic chemistry , combinatorial chemistry , medicinal chemistry , genetics , biology
In order to find novel high activity and low toxicity agrochemicals, a series of novel thiophosphoryl oximates containing thiazole and 1,2,3‐triazole rings 4 were synthesized by the reactions of 1‐{1‐[(2‐chlorothiazol‐5‐ yl)methyl]‐5‐methyl‐1 H ‐1,2,3‐triazol‐4‐yl}ethanone oxime with various asymmetric thiophosphoryl chlorides. Their structures were confirmed by IR, 1 H NMR, 31 P NMR, EI‐MS and elemental analyses. The target compounds existed as E ‐configuration, which was deduced by NMR analysis and by comparison with their pyridyl analog determined by X‐ray diffraction. The results of preliminary bioassay indicate that some of title compounds possess moderate insecticidal and fungicidal activities.