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Asymmetric Alkynylation of Aldehydes Catalyzed by Bifunctional Zinc(salen) Complex
Author(s) -
SHEN Chun,
CHEN Lei,
TANG Jie,
XU Minghua
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990068
Subject(s) - chemistry , bifunctional , alkynylation , catalysis , zinc , reactivity (psychology) , ligand (biochemistry) , stereoselectivity , enantioselective synthesis , combinatorial chemistry , polymer chemistry , organic chemistry , medicine , biochemistry , alternative medicine , receptor , pathology
The asymmetric alkynylation of aldehydes catalyzed by bifunctional Zn(salen) catalyst was realized. With a Kozlowski salen ligand (7e) bearing secondary basic 1‐piperidinylmethyl groups at C‐3 and C‐3′, the enhanced catalytic reactivity and stereoselectivity in comparison with that of normal salen ligands in the alkynylzinc addition to aldehydes were observed.