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Synthesis and Preliminary Anti‐leukemia Activity of N ‐(Substituted Benzyl)‐4‐hydroxy‐4‐substituted Piperidine Derivatives
Author(s) -
FANG Zhikun,
XUE Sijia,
CHEN Long,
XU Yang,
YIN Anqin,
LI Chunyan
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990065
Subject(s) - chemistry , reagent , piperidine , hydrolysis , decarboxylation , k562 cells , leukemia , organic chemistry , stereochemistry , combinatorial chemistry , in vitro , biochemistry , catalysis , medicine
In order to find some lead compounds with high inhibition against leukemia, twelve unreported compounds 6a – 6l have been synthesized with substituted benzylamines as raw materials via a series of Michael addition, Dieckmann condensation, hydrolysis decarboxylation and reactions with Grignard reagent. Complete assignments have been achieved for the title compounds by 1 H NMR, IR, MS and elemental analysis. The preliminary anti‐tumor activity tests indicate that the title compounds have good effect on the cellular growth inhibition against K562 cells and have potential anti‐leukemia bioactivity.