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Tin(II) Chloride Dihydrate Catalyzed Groebke Condensation: An Efficient Protocol for the Synthesis of 3‐Aminoimidazo[1,2‐ a ]pyridines
Author(s) -
SHAABANI Ahmad,
SOLEIMANI Ebrahim,
SARVARY Afshin,
REZAYAN Ali Hossein,
MALEKI Ali
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990060
Subject(s) - chemistry , tin , catalysis , condensation , chloride , lewis acid catalysis , reaction conditions , condensation reaction , lewis acids and bases , combinatorial chemistry , organic chemistry , medicinal chemistry , physics , thermodynamics
The ability of tin(II) chloride dihydrate as a catalyst to promote the three‐component condensation reaction from a diversity of aromatic aldehydes, 2‐aminopyridines and isonitriles at room temperature is described. This methodology affords a number of 3‐aminoimidazo[1,2‐ a ]pyridines in the presence of tin(II) chloride dihydrate as a new and mild Lewis acid catalyst in the multi‐component reaction in reasonable yields and short reaction time without any significant optimization of the reaction conditions.