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Xanthones from the Bark of Garcinia xanthochymus and Their 1,1‐Diphenyl‐2‐picrylhydrazyl Radical‐Scavenging Activity
Author(s) -
ZHONG Fangfang,
CHEN Yu,
WANG Ping,
FENG Huijin,
YANG Guangzhong
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990029
Subject(s) - chemistry , xanthone , dpph , garcinia , bark (sound) , scavenging , antioxidant , clusiaceae , stereochemistry , organic chemistry , traditional medicine , medicine , physics , acoustics
Five new xanthones, garcinenone A ( 1 ), B ( 3 ), C ( 4 ), D ( 7 ) and E ( 8 ), along with 7 known compounds were isolated from the EtOAc‐soluble extract of the bark of Garcinia xanthochymus , and their structures were elucidated by spectroscopic methods, especially 2D‐NMR techniques. Jacareubin ( 2 ), 1,4,6‐trihydroxy‐5‐methoxy‐7‐(3‐methyl‐2‐butenyl)xanthone ( 6 ), subeliptenone B ( 11 ) and symphoxanthone ( 12 ) were obtained from this plant for the first time. The isolated compounds exhibited potent antioxidant activity in the 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging test with IC 50 values in the 6.0–23.2 µmol/L. These results suggested that G. xanthochymus could be a promising rich source of natural antioxidant.