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Stereocontrolled Synthesis of ( E )‐ β , γ ‐Unsaturated Esters via Palladium‐Catalyzed Cross‐Coupling of ( E )‐Alkenylboronic Acids with α ‐Bromoacetic Esters
Author(s) -
DUAN Yazhen,
ZHANG Jianshe,
YANG Jun,
DENG Minzhi
Publication year - 2009
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200990014
Subject(s) - chemistry , catalysis , biphenyl , palladium , coupling reaction , organic chemistry , ligand (biochemistry) , coupling (piping) , medicinal chemistry , receptor , mechanical engineering , biochemistry , engineering
The cross‐coupling reaction of trans ‐alkenylboronic acids with ???α????‐bromoacetic esters was firstly studied. It was found that using Pd(OAc) 2 as catalyst, a bulky electron‐rich phospine, (2‐dicyclohexylphospino‐biphenyl) as ligand, the reaction can be readily accomplished to give specific ( E )‐???β γ????‐unsaturated esters in high yields.