Stereocontrolled Synthesis of ( E )‐ β , γ ‐Unsaturated Esters via Palladium‐Catalyzed Cross‐Coupling of ( E )‐Alkenylboronic Acids with  α  ‐Bromoacetic Esters | Zendy

DUAN Yazhen | Zendy; ZHANG Jianshe | Zendy; YANG Jun | Zendy; DENG Minzhi | Zendy

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Stereocontrolled Synthesis of ( E )‐ β , γ ‐Unsaturated Esters via Palladium‐Catalyzed Cross‐Coupling of ( E )‐Alkenylboronic Acids with α ‐Bromoacetic Esters

Author(s) -

DUAN Yazhen,

ZHANG Jianshe,

YANG Jun,

DENG Minzhi

Publication year - 2009

Publication title -

chinese journal of chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.28

H-Index - 41

eISSN - 1614-7065

pISSN - 1001-604X

DOI - 10.1002/cjoc.200990014

Subject(s) - chemistry , catalysis , biphenyl , palladium , coupling reaction , organic chemistry , ligand (biochemistry) , coupling (piping) , medicinal chemistry , receptor , mechanical engineering , biochemistry , engineering

The cross‐coupling reaction of trans ‐alkenylboronic acids with ???α????‐bromoacetic esters was firstly studied. It was found that using Pd(OAc) 2 as catalyst, a bulky electron‐rich phospine, (2‐dicyclohexylphospino‐biphenyl) as ligand, the reaction can be readily accomplished to give specific ( E )‐???β γ????‐unsaturated esters in high yields.

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