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Simple Lanthanide Amides [(Me 3 Si) 2 N] 3 Ln( µ ‐Cl)Li(THF) 3 as Highly Efficient Catalysts for the Nitroaldol Reaction
Author(s) -
LIU YuYu,
WANG ShaoWu,
ZHANG LiJun,
WU YunJun,
LI QingHai,
YANG GaoSheng,
XIE MeiHua
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890402
Subject(s) - chemistry , chemoselectivity , lanthanide , catalysis , nitroaldol reaction , aldehyde , reaction conditions , organic chemistry , combinatorial chemistry , medicinal chemistry , enantioselective synthesis , ion
This contribution is to report the application of simple lanthanide amides [(Me 3 Si) 2 N] 3 Ln( µ ‐Cl)Li(THF) 3 exhibiting a high activity toward catalyzing Henry reaction of aromatic aldehydes with nitroalkanes to give β ‐nitroalcohols or β ‐nitroolefins with a very good chemoselectivity by controlling the reaction temperatures and by selecting aromatic aldehydes. It was found that this catalytic system was compatible with a wide range of substrates of aldehydes.