Premium
Synthesis and Structural Studies of 1‐Deoxybaccatin VI Derivatives
Author(s) -
LIN HaiXia,
WANG DianLong,
CHEN JianMin,
CHEN MinQin
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890337
Subject(s) - chemistry , moiety , stereochemistry , ring (chemistry) , acetylation , acetonide , organic chemistry , biochemistry , gene , medicine , surgery , triamcinolone acetonide
Synthesis and crystal structures of 1‐deoxybaccatin VI derivatives, and the influence of C(9), C(10), and C(13) substituents of the tetracyclic moiety on molecular conformations were investigated. Comparison of conformations of 1‐deoxybaccatin VI derivatives reveals subtle conformational variations in the tetracyclic ring system due to deacetylation at C(10) and C(13), and 9,10‐acetonide. Additionally, C(2)‐benzoyl group exhibits an unexpected conformational flexibility in 1‐deoxybaccatin VI derivatives, which may be relevant to the bioactivity of taxanes.