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Synthesis and Characterization of Camptothecin Intercalated into Mg/Al Layered Double Hydroxide
Author(s) -
LIU ChunXia,
HOU WanGuo,
LI Yan,
LI LiFang
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890325
Subject(s) - chemistry , camptothecin , hydroxide , layered double hydroxides , intercalation (chemistry) , bilayer , molecule , coprecipitation , kinetics , nuclear chemistry , inorganic chemistry , membrane , organic chemistry , biochemistry , physics , quantum mechanics
The intercalation of camptothecin (CPT) into a layered inorganic host, Mg‐Al layered double hydroxide (LDH), was carried out using a coprecipitation method to obtain CPT‐LDH nanohybrids. It was found that the intercalated amounts ( A in ) of CPT‐LDH nanohybrids were remarkably dependent on the molar ratios ( R C/M ) of CPT to metal ions in raw materials. The A in value increases with the R C/M value increasing. According to the gallery heights of CPT‐LDH and sizes of CPT molecule, a probably morphology of CPT molecules in the gallery of LDH was suggested that the horizontal‐arranged monolayer and vertical‐arranged bilayer of CPT molecules coexisted in the interlayer region of LDH. An interesting result was found that the gallery height corresponding to the bilayer of CPT‐LDH sample with a high A in value was remarkably lower than that with low A in value. The in vitro CPT release examinations from the nanohybrids showed that the CPT‐LDH nanohybrids were a potential drug controlled release system. The kinetic analysis showed that the release kinetics of CPT from the nanohybrids obeyed the pseudo‐first order kinetic model and the diffusion of CPT through the LDH particle of CPT played an important role in controlling the drug release rate.