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Preparation of Silyl Ethers Using Hexamethyldisilazane in the Presence of N ‐Bromosuccinimide under Mild and Solvent‐Free Conditions
Author(s) -
SHATERIAN Hamid Reza,
DOOSTMOHAMMADI Razieh,
GHASHANG Majid
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890309
Subject(s) - chemistry , n bromosuccinimide , silylation , trimethylsilyl , organic chemistry , solvent , catalysis , primary (astronomy) , reaction conditions , halogenation , physics , astronomy
A mild, simple, novel and highly efficient method for the rapid protection of various primary, secondary, tertiary aliphatic and aromatic alcohols using hexamethyldisilazane (HMDS) in the presence of N ‐bromosuccinimide (NBS) as an active, inexpensive, non‐toxic and readily available catalyst under solvent‐free conditions is described. Trimethylsilyl ethers were prepared in high to excellent yields with short reaction time under mild and almost neutral reaction conditions.