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Synthesis of 5‐Androstene‐3 β ,7 α ,17 β ‐triol and 5‐Androstene‐3 β ,7 β ,17 β ‐triol
Author(s) -
LI HePing,
YU Peng,
ZHANG HongJie,
LIU HongMin
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890301
Subject(s) - chemistry , triol , transformation (genetics) , mucor , organic chemistry , diol , biochemistry , food science , gene , penicillium
Two important neuroactive steroids 5‐androstene‐3 β ,7 α ,17 β ‐triol ( 6 ) and 5‐androstene‐3 β ,7 β ,17 β ‐triol ( 7 ) were prepared through a microbial transformation of 5‐androstene‐3 β ,17 β ‐diol, which was the first report for the synthesis of compounds 6 and 7 through a microbial transformation with Mucor racemosu isolated by ourselves.