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Asymmetric Hydrogenation of α ‐Hydroxy Ketones: A Reaction Sensitive toward Electronic Effect of Substrates
Author(s) -
XU Hui,
MENG QingHua,
ZHANG ZhaoGuo
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890299
Subject(s) - chemistry , asymmetric hydrogenation , catalysis , benzene , noyori asymmetric hydrogenation , enantioselective synthesis , organic chemistry , ketone , medicinal chemistry , combinatorial chemistry
An efficient asymmetric hydrogenation of α ‐hydroxy ketones was reported with the catalyst prepared from [RuCl 2 (benzene)] 2 and SunPhos, chiral terminal 1,2‐diols were obtained in up to 99% ee . This Ru‐catalyzed asymmetric hydrogenation reaction of α ‐hydroxy ketones represents a new route for the synthesis of chiral terminal 1,2‐diols.
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