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An Efficient Synthesis of Polysubstituted 1,3‐Enynes from ( E )‐ β ‐Iodovinyl Sulfones and Terminal Alkynes
Author(s) -
GU XiaoXia,
XIE MeiHua,
ZHAO XinYang,
SUN Ying,
ZHANG Wei,
XIE FaDong,
WANG ShaoWu
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890293
Subject(s) - chemistry , sonogashira coupling , sulfonyl , terminal (telecommunication) , coupling (piping) , reagent , medicinal chemistry , combinatorial chemistry , organic chemistry , palladium , catalysis , mechanical engineering , telecommunications , alkyl , computer science , engineering
Sulfonyl‐substituted 1,3‐enynes were synthesized in moderate to high yields by Sonogashira coupling reaction of ( E )‐ β ‐iodovinyl sulfones with terminal alkynes. The sulfonyl group was further transformed to various substitutents by desulfonylation coupling with Grignard reagents in the presence of NiCl 2 (PPh 3 ) 2 .
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