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Synthesis of Polyfunctionally Substituted Fused Pyrimidine Derivatives as Antimicrobial Agents
Author(s) -
EISSA Abd EIMonem Mohamed Farag
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890273
Subject(s) - chemistry , pyrimidine , antimicrobial , reagent , combinatorial chemistry , organic chemistry , stereochemistry
A variety of pyrimidine derivatives 2 – 4 and annulated pyrimidine derivatives 5 – 17 have been synthesized via a sequence of heterocyclization reaction of readily available 6‐naphthyl‐4‐oxo‐2‐thioxo‐1,2,3,4‐tetrahydroprimidine‐5‐carbonitrile ( 1 ) with different acidic and basic reagents. The new compounds were synthesized with the aim of study of their antimicrobial activity. The structures of all synthesized compounds were elucidated by elemental analysis and spectroscopic studies.