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Gold‐catalyzed Alkyne Hydroxylation: Synthesis of 2‐Substituted Benzo[ b ]furan Compounds
Author(s) -
ZHANG Yuan,
XIN ZhiJun,
XUE JiJun,
LI Ying
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890265
Subject(s) - chemistry , alkyne , furan , sonogashira coupling , hydroxylation , catalysis , phenols , phenol , organic chemistry , combinatorial chemistry , palladium , enzyme
A strategy concerning the synthesis of 2‐substituted benzo[ b ]furan compounds from o ‐alkynyl phenols via a gold‐catalyzed alkyne hydroxylation is described, which allows the rapid synthesis of various 2‐substituted benzo[ b ]furan derivatives in excellent yields under mild conditions. The o ‐alkynyl phenol precursors were readily prepared with a Sonogashira coupling reaction.