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Investigation on a Potential Targeting Drug Delivery System Consisting of Folate, Mitoxantrone and Human Serum Albumin
Author(s) -
ZHOU QiuJu,
BI YaJing,
XIANG JunFeng,
TANG YaLin,
YANG QianFan,
XU GuangZhi
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890252
Subject(s) - chemistry , human serum albumin , mitoxantrone , drug delivery , cytotoxicity , drug , pharmacology , albumin , delivery system , biochemistry , in vitro , organic chemistry , chemotherapy , medicine , surgery
A potential targeting drug delivery system consisting of folate (FA), the targeting molecule, human serum albumin (HSA), the carrier, and mitoxantrone (MTO), the medicine, has been designed. Data obtained by UV absorption, fluorescence, and NMR techniques indicated the formation of ternary complexes and possible application to building a targeting drug delivery system by using FA, MTO and HSA. Furthermore, cytotoxicity assay indicated that the toxicity of the FA‐HSA‐MTO against PC‐3 cell line was 79.95%, which was much higher than that of free MTO tested in totally the same conditions. About 30% increase of the toxicity should be owed to the targeting effect of FA. Thus, the feasibility and validity of a novel targeting drug delivery system, FA‐HSA‐MTO, was confirmed.