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Synthesis of β ‐Amino Acids via Catalyst‐ and Solvent‐Free Aza‐Michael Reaction
Author(s) -
ZOU Bo,
JIANG HuanFeng
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890238
Subject(s) - chemistry , michael reaction , catalysis , environmentally friendly , organic chemistry , amino acid , solvent , combinatorial chemistry , biochemistry , ecology , biology
A safe, environmentally friendly and cost‐effective method for the synthesis of β ‐amino acid derivatives has been developed. Treatment of α , β ‐unsaturated compounds with aliphatic amines furnishes β ‐amino acid derivatives in good to excellent yields via a catalyst‐ and solvent‐free aza‐Michael addition.