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A Green Approach to the Synthesis of Biologically Important Indeno[2,1‐ e ]pyrazolo[5,4‐ b ]pyridines via Microwave‐assisted Multi‐component Reactions in Water
Author(s) -
SHI Feng,
ZHANG Yan,
TU ShuJiang,
ZHOU DianXiang,
LI ChunMei,
SHAO QingQing,
CAO LongJi
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890229
Subject(s) - chemistry , aldehyde , microwave irradiation , component (thermodynamics) , catalysis , scope (computer science) , microwave , amine gas treating , combinatorial chemistry , green chemistry , organic chemistry , reaction mechanism , telecommunications , physics , computer science , thermodynamics , programming language
A green approach to the synthesis of biologically important indeno[2,1‐ e ]pyrazolo[5,4‐ b ]pyridines was successfully realized via multi‐component reactions of aldehyde, 3‐methyl‐1‐phenyl‐1 H ‐pyrazol‐5‐amine and 1,3‐indanedione in water under microwave irradiation without catalyst. This protocol has the prominent advantages of environmental‐friendliness, short reaction time, excellent yields, low cost, easy operation as well as broad scope of applicability.