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An Efficient Synthesis of 1,5‐Benzodiazepine Derivatives by Lanthanide Trichloride‐catalyzed Condensation of o ‐Phenylenediamine with α , β ‐Unsaturated Ketone under Mild Conditions
Author(s) -
FENG ShanE,
XU Fan,
SHEN Qi
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890213
Subject(s) - chemistry , lanthanide , catalysis , condensation , ketone , o phenylenediamine , ytterbium , condensation reaction , organic chemistry , methyl ketone , medicinal chemistry , polymer chemistry , doping , ion , physics , optoelectronics , thermodynamics
The condensation of o ‐phenylenediamine with various α , β ‐unsaturated ketones was efficiently catalyzed by lanthanide trichloride and a variety of 1,5‐benzodiazepines were synthesized in moderate to high yields under mild conditions. The reactions catalyzed by ytterbium trichloride were investigated emphatically.