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Design, Synthesis and Antitumor Activity of Asymmetric Bis( s ‐triazole Schiff‐base)s Bearing Functionalized Side‐Chain
Author(s) -
HU GuoQiang,
HOU LiLi,
XIE SongQiang,
HUANG WenLong
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890205
Subject(s) - chemistry , chloroacetic acid , schiff base , triazole , 1,2,4 triazole , side chain , stereochemistry , mtt assay , in vitro , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , polymer
1‐Amino‐2‐pyrid‐3‐yl‐5‐(2‐benzoylethylthio)‐ s ‐triazole ( 1 ) was condensed with 1‐amino‐3‐mercapto‐5‐ [(un)substituted phenyl]‐ s ‐triazoles and subsequently substituted with chloroacetic acid to afford bis‐ s ‐triazole sulfanylacetic acid mono‐Schiff bases ( 3a – 3e ), which were condensed with 9‐formylanthracene to produce asymmetric bis( s ‐triazole Schiff base) sulfanylacetic acids ( 4a – 4e ). The structures of new synthesized compounds were characterized by elemental analysis and spectral data, and their in vitro antitumor activity against L1210, CHO and HL60 cell lines was evaluted via the respective IC 50 values by methylthiazole trazolium (MTT) assay.