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Synthesis and Bioactivity of Novel N , N′ ‐Diacylhydrazine Derivatives Containing Furan(I)
Author(s) -
CUI ZiNing,
HUANG Juan,
LI Ying,
LING Yun,
YANG XinLing,
CHEN FuHeng
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890168
Subject(s) - chemistry , furan , dichloromethane , ring (chemistry) , anhydrous , proton nmr , organic chemistry , elemental analysis , chloride , combinatorial chemistry , medicinal chemistry , solvent
The furan ring system possesses electron‐rich properties and exhibits various biological activities, which was introduced into diacylhydrazine to create novel leading compounds that may serve as improved pesticides and pharmaceuticals. A series of novel diacylhydrazine derivatives containing a furan ring were synthesized by the reaction of 5‐fluorophenyl‐2‐furoyl chloride with substituted benzoylhydrazide in anhydrous dichloromethane under reflux. The structures of the resultant compounds were confirmed by IR, 1 H NMR, MS and elemental analysis. Insecticidal and anti‐tumor activities of these new compounds were evaluated.