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L ‐Proline‐based Phosphamides as a New Kind of Organocatalyst for Asymmetric Direct Aldol Reactions
Author(s) -
YU Guo,
GE ZeMei,
CHENG TieMing,
LI RunTao
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890167
Subject(s) - chemistry , aldol reaction , proline , organocatalysis , catalysis , organic chemistry , combinatorial chemistry , enantioselective synthesis , biochemistry , amino acid
Four L ‐proline‐based phosphamides were designed and synthesized as a new kind of organocatalyst. Their catalytic activities for asymmetric direct aldol reactions were evaluated. Among them, 3a with 10 mol% catalyst loading afforded moderate to good yields and up to 99% ee .
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