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Determination of Rifampicin by Peroxomonosulfate‐Cobalt(II) Chemiluminescence System
Author(s) -
MA Yong,
ZHANG BoTao,
ZHAO LiXia,
GUO GuangSheng,
LIN JinMing
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890166
Subject(s) - chemistry , chemiluminescence , rifampicin , detection limit , relative standard deviation , chromatography , linear range , analytical chemistry (journal) , antibiotics , biochemistry
Rifampicin can enhance the chemiluminescence (CL) of peroxomonosulfate‐cobalt(II) system, and the CL intensity is strongly dependent on the rifampicin concentrations. Based on this phenomenon, a rapid and sensitive flow injection CL method was developed for the determination of rifampicin. The relative CL intensity was linear with the rifampicin concentration over the range of 5×10 −8 to 1×10 −6 g·mL −1 ( r =0.9991), the detection limit was 7×10 −9 g·mL −1 ( S / N =3), and the relative standard deviation was 2.7% for 6×10 −7 g·mL −1 rifampicin ( n =11). Furthermore, this method was successfully applied to the determination of rifampicin in real eye drop and capsules sample.