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Silica‐gel‐supported Phosphorus Pentoxide:a Simple and Efficient Solid‐supported Reagent for Esterification of Long‐ Chain Carboxylic Acids and Their Antimicrobial Screening
Author(s) -
RAUF Abdul,
GANGAL Saloni,
SHARMA Shweta
Publication year - 2008
Publication title -
chinese journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.28
H-Index - 41
eISSN - 1614-7065
pISSN - 1001-604X
DOI - 10.1002/cjoc.200890132
Subject(s) - chemistry , phosphorus pentoxide , reagent , silica gel , pentoxide , organic chemistry , antimicrobial , phosphorus , proton nmr , antifungal , elemental analysis , antibacterial activity , bacteria , microbiology and biotechnology , vanadium , genetics , biology
A silica‐gel‐supported heterogeneous phosphorus pentoxide reagent has been developed for the esterification of various long‐chain carboxylic acids with aromatic alcohols. The reactions occurred under relatively mild conditions and afforded the desired products in good yields. All the compounds 3a – 3x were screened for antibacterial and antifungal activity, which showed good activity against Gram positive and Gram negative bacteria and also good results against almost all fungal strains. The structures of the synthesized compounds were elucidated by IR, 1 H NMR, 13 C NMR, mass spectroscopic techniques and elemental analysis.